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Assay Detail

CHEMBL911121

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]RTI-55 from human SERT expressing HEK293 cells
ChEMBL ↗
55
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Expert

Target

Sodium-dependent serotonin transporter (CHEMBL228) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.
Froimowitz M, Gu Y, Dakin LA, Nagafuji PM, Kelley CJ, Parrish D, Deschamps JR, Janowsky A.
J Med Chem (2007) 50 : 219 -232
PubMed 17228864 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 55 5.57 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL370805 COCAINE 4.0 1 6.47
CHEMBL219649 — — 2 6.35
CHEMBL218999 — — 2 6.35
CHEMBL219281 — — 2 6.19
CHEMBL441864 — — 2 6.16
CHEMBL219707 — — 2 6.05
CHEMBL218894 — — 2 6.02
CHEMBL374634 — — 2 5.96
CHEMBL373773 — — 2 5.96
CHEMBL387117 — — 2 5.89
CHEMBL220195 — — 2 5.80
CHEMBL218193 — — 2 5.77
CHEMBL219703 — — 2 5.66
CHEMBL218847 — — 2 5.57
CHEMBL219653 — — 2 5.54
CHEMBL219335 — — 2 5.50
CHEMBL374769 — — 2 5.46
CHEMBL217975 — — 2 5.42
CHEMBL219334 — — 2 5.41
CHEMBL376852 — — 2 5.38
CHEMBL218849 — — 2 5.37
CHEMBL220247 — — 2 5.37
CHEMBL375118 — — 2 5.34
CHEMBL219224 — — 2 5.31
CHEMBL373710 — — 2 5.30
CHEMBL218848 — — 2 5.28
CHEMBL219116 — — 2 5.23
CHEMBL219540 — — 1 5.11
CHEMBL796 METHYLPHENIDATE 4.0 1 4.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL370805 COCAINE Ki = 340.0 nM 6.47
CHEMBL219649 — Ki = 450.0 nM 6.35
CHEMBL218999 — Ki = 450.0 nM 6.35
CHEMBL219281 — Ki = 640.0 nM 6.19
CHEMBL441864 — Ki = 700.0 nM 6.16
CHEMBL219707 — Ki = 900.0 nM 6.05
CHEMBL218894 — Ki = 950.0 nM 6.02
CHEMBL374634 — Ki = 1100.0 nM 5.96
CHEMBL373773 — Ki = 1100.0 nM 5.96
CHEMBL374634 — Ki = 1300.0 nM 5.89
CHEMBL387117 — Ki = 1300.0 nM 5.89
CHEMBL387117 — Ki = 1500.0 nM 5.82
CHEMBL441864 — Ki = 1500.0 nM 5.82
CHEMBL220195 — Ki = 1600.0 nM 5.80
CHEMBL218999 — Ki = 1600.0 nM 5.80
CHEMBL218193 — Ki = 1700.0 nM 5.77
CHEMBL219281 — Ki = 1800.0 nM 5.75
CHEMBL219649 — Ki = 1800.0 nM 5.75
CHEMBL219703 — Ki = 2200.0 nM 5.66
CHEMBL220195 — Ki = 2500.0 nM 5.60
CHEMBL218847 — Ki = 2700.0 nM 5.57
CHEMBL218894 — Ki = 2800.0 nM 5.55
CHEMBL219653 — Ki = 2900.0 nM 5.54
CHEMBL218847 — Ki = 3200.0 nM 5.50
CHEMBL219335 — Ki = 3200.0 nM 5.50
CHEMBL219653 — Ki = 3200.0 nM 5.50
CHEMBL219335 — Ki = 3200.0 nM 5.50
CHEMBL218193 — Ki = 3300.0 nM 5.48
CHEMBL374769 — Ki = 3500.0 nM 5.46
CHEMBL219703 — Ki = 3600.0 nM 5.44
CHEMBL219707 — Ki = 3700.0 nM 5.43
CHEMBL217975 — Ki = 3800.0 nM 5.42
CHEMBL219334 — Ki = 3900.0 nM 5.41
CHEMBL374769 — Ki = 3900.0 nM 5.41
CHEMBL376852 — Ki = 4200.0 nM 5.38
CHEMBL217975 — Ki = 4200.0 nM 5.38
CHEMBL218849 — Ki = 4300.0 nM 5.37
CHEMBL373773 — Ki = 4300.0 nM 5.37
CHEMBL220247 — Ki = 4300.0 nM 5.37
CHEMBL375118 — Ki = 4600.0 nM 5.34
CHEMBL218849 — Ki = 4800.0 nM 5.32
CHEMBL219334 — Ki = 4800.0 nM 5.32
CHEMBL219224 — Ki = 4900.0 nM 5.31
CHEMBL373710 — Ki = 5000.0 nM 5.30
CHEMBL218848 — Ki = 5300.0 nM 5.28
CHEMBL375118 — Ki = 5700.0 nM 5.24
CHEMBL220247 — Ki = 5900.0 nM 5.23
CHEMBL219116 — Ki = 5900.0 nM 5.23
CHEMBL219116 — Ki = 6000.0 nM 5.22
CHEMBL373710 — Ki = 6700.0 nM 5.17