Assay Detail
Binding
CHEMBL919045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2A receptor in Wistar Han rat cortex membranes
20
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.18 | 7.11 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222188 | — | — | 1 | 7.11 |
| CHEMBL224883 | — | — | 1 | 6.85 |
| CHEMBL374297 | — | — | 1 | 6.59 |
| CHEMBL222755 | — | — | 1 | 6.58 |
| CHEMBL225571 | — | — | 1 | 6.55 |
| CHEMBL222477 | — | — | 1 | 6.52 |
| CHEMBL225284 | — | — | 1 | 6.49 |
| CHEMBL221513 | — | — | 1 | 6.16 |
| CHEMBL224935 | — | — | 1 | 6.04 |
| CHEMBL374298 | — | — | 1 | 5.95 |
| CHEMBL225512 | — | — | 1 | 5.47 |
| CHEMBL374261 | — | — | 1 | 5.14 |
| CHEMBL389718 | — | — | 1 | 4.91 |
| CHEMBL222275 | — | — | 1 | - |
| CHEMBL225171 | — | — | 1 | - |
| CHEMBL222507 | — | — | 1 | - |
| CHEMBL387738 | — | — | 2 | - |
| CHEMBL222489 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222188 | — | Ki | = | 77.8 | nM | 7.11 |
| CHEMBL224883 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL374297 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL222755 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL225571 | — | Ki | = | 282.0 | nM | 6.55 |
| CHEMBL222477 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL225284 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL221513 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL224935 | — | Ki | = | 909.0 | nM | 6.04 |
| CHEMBL374298 | — | Ki | = | 1127.0 | nM | 5.95 |
| CHEMBL225512 | — | Ki | = | 3394.0 | nM | 5.47 |
| CHEMBL374261 | — | Ki | = | 7168.0 | nM | 5.14 |
| CHEMBL389718 | — | Ki | = | 12200.0 | nM | 4.91 |
| CHEMBL222275 | — | Ki | - | — | - | |
| CHEMBL225171 | — | Ki | - | — | - | |
| CHEMBL222507 | — | Ki | - | — | - | |
| CHEMBL387738 | — | Activity | = | 38.0 | % | - |
| CHEMBL387738 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL222489 | — | Activity | = | 9.0 | % | - |
| CHEMBL222489 | — | Ki | > | 4000.0 | nM | - |