Assay Detail
Binding
CHEMBL921164
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Inhibition of HDAC1 in rat liver extract
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.95 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360194 | — | — | 1 | 7.68 |
| CHEMBL259517 | — | — | 1 | 6.89 |
| CHEMBL140000 | — | — | 1 | 6.62 |
| CHEMBL113003 | — | — | 1 | 6.36 |
| CHEMBL261492 | — | — | 1 | 6.24 |
| CHEMBL259708 | — | — | 1 | 6.23 |
| CHEMBL259434 | — | — | 1 | 6.20 |
| CHEMBL261272 | — | — | 1 | 5.78 |
| CHEMBL260080 | — | — | 1 | 5.68 |
| CHEMBL261587 | — | — | 1 | 5.61 |
| CHEMBL409860 | — | — | 1 | 5.59 |
| CHEMBL264411 | — | — | 1 | 5.52 |
| CHEMBL264926 | — | — | 1 | 5.52 |
| CHEMBL406734 | — | — | 1 | 5.50 |
| CHEMBL409526 | — | — | 1 | 5.50 |
| CHEMBL427776 | — | — | 1 | 5.12 |
| CHEMBL259826 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360194 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL259517 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL140000 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL113003 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL261492 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL259708 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL259434 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL261272 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL260080 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL261587 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL409860 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL264411 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL264926 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL406734 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL409526 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL427776 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL259826 | — | IC50 | = | 8760.0 | nM | 5.06 |