Assay Detail
Binding
CHEMBL924095
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Inhibition of 15-hLO1
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.43 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239247 | — | — | 1 | 6.82 |
| CHEMBL239893 | — | — | 1 | 6.68 |
| CHEMBL239033 | — | — | 1 | 6.68 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.60 |
| CHEMBL239677 | — | — | 1 | 6.46 |
| CHEMBL8328 | — | — | 1 | 6.29 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 5.85 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.66 |
| CHEMBL239276 | — | — | 1 | 5.48 |
| CHEMBL391342 | — | — | 1 | 5.43 |
| CHEMBL391341 | — | — | 1 | 5.24 |
| CHEMBL241815 | — | — | 1 | 5.21 |
| CHEMBL395449 | — | — | 1 | 5.11 |
| CHEMBL238844 | — | — | 1 | 5.08 |
| CHEMBL241814 | — | — | 1 | 5.05 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 5.04 |
| CHEMBL238843 | — | — | 1 | 4.96 |
| CHEMBL241813 | — | — | 1 | 4.89 |
| CHEMBL394257 | — | — | 1 | 4.75 |
| CHEMBL239031 | — | — | 1 | 4.72 |
| CHEMBL395346 | — | — | 1 | 4.42 |
| CHEMBL239156 | — | — | 1 | 4.31 |
| CHEMBL294009 | FLAVONOL | — | 1 | 4.14 |
| CHEMBL210276 | 3,7-DIHYDROXYFLAVONE | — | 1 | - |
| CHEMBL138649 | 6-HYDROXYFLAVONE | — | 1 | - |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | - |
| CHEMBL238813 | — | — | 1 | - |
| CHEMBL239053 | — | — | 1 | - |
| CHEMBL239032 | — | — | 1 | - |
| CHEMBL239030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239247 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL239893 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL239033 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL239677 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL8328 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL31574 | FISETIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL50 | QUERCETIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL239276 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL391342 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL391341 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL241815 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL395449 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL238844 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL241814 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL238843 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL241813 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL394257 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL239031 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL395346 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL239156 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL294009 | FLAVONOL | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL238815 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL238814 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210411 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL238812 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL241366 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL241365 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL396673 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL241364 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL241363 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL147999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL395115 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL240713 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL240505 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL238816 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL394258 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL239022 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL239023 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL241794 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL239028 | FORMONETIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL238821 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL239030 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL239032 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL239053 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL238813 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL276915 | 7-HYDROXYFLAVONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL138649 | 6-HYDROXYFLAVONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL210276 | 3,7-DIHYDROXYFLAVONE | IC50 | > | 100000.0 | nM | - |