Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL928706

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen epimastigotes after 72 hrs
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives.
Rebollo O, del Olmo E, Ruiz G, López-Pérez JL, Giménez A, San Feliciano A.
Bioorg Med Chem Lett (2008) 18 : 184 -187
PubMed 18024033 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.62 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL254735 1 6.92
CHEMBL254534 1 6.85
CHEMBL254329 1 6.82
CHEMBL254734 1 6.72
CHEMBL254940 1 6.62
CHEMBL254532 1 6.57
CHEMBL252907 1 5.92
CHEMBL254733 1 5.13
CHEMBL254939 1 5.07
CHEMBL254938 1 5.06
CHEMBL403416 1 4.51
CHEMBL413992 1 4.29
CHEMBL110 BENZNIDAZOLE 4.0 1 4.13
CHEMBL252908 1 4.01
CHEMBL403417 1 -
CHEMBL403198 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL254735 IC50 = 120.0 nM 6.92
CHEMBL254534 IC50 = 140.0 nM 6.85
CHEMBL254329 IC50 = 150.0 nM 6.82
CHEMBL254734 IC50 = 190.0 nM 6.72
CHEMBL254940 IC50 = 240.0 nM 6.62
CHEMBL254532 IC50 = 270.0 nM 6.57
CHEMBL252907 IC50 = 1200.0 nM 5.92
CHEMBL254733 IC50 = 7400.0 nM 5.13
CHEMBL254939 IC50 = 8600.0 nM 5.07
CHEMBL254938 IC50 = 8800.0 nM 5.06
CHEMBL403416 IC50 = 31000.0 nM 4.51
CHEMBL413992 IC50 = 51000.0 nM 4.29
CHEMBL110 BENZNIDAZOLE IC50 = 74000.0 nM 4.13
CHEMBL252908 IC50 = 98000.0 nM 4.01
CHEMBL403417 IC50 = 116000.0 nM -
CHEMBL403198 IC50 = 106000.0 nM -