Assay Detail
Binding
CHEMBL942233
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Inhibition of ovine COX1 by enzyme immuno assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.48 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.52 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.54 |
| CHEMBL745 | PRIMARY ALCOHOL METABOLITE OF CELECOXIB | — | 1 | 5.15 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.11 |
| CHEMBL486763 | — | — | 1 | 5.07 |
| CHEMBL500062 | — | — | 1 | - |
| CHEMBL503018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL745 | PRIMARY ALCOHOL METABOLITE OF CELECOXIB | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL486763 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL500062 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL503018 | — | IC50 | - | — | - |