Assay Detail
Functional
CHEMBL945996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit rho-1 (CHEMBL3561) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.72 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 5.92 |
| CHEMBL290216 | — | — | 1 | 4.72 |
| CHEMBL403157 | — | — | 1 | 4.40 |
| CHEMBL296263 | — | — | 1 | 4.35 |
| CHEMBL256608 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL290216 | — | EC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL403157 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL296263 | — | EC50 | = | 44800.0 | nM | 4.35 |
| CHEMBL256608 | — | EC50 | = | 65000.0 | nM | 4.19 |