Assay Detail
Functional
CHEMBL952132
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of serotonin release in bovine platelets
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Neural networks as valuable tools to differentiate between sesquiterpene lactones' inhibitory activity on serotonin release and on NF-kappaB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 4.95 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270551 | URSINIOLIDE A | — | 1 | 5.75 |
| CHEMBL264922 | CINERENIN ACETATE | — | 1 | 5.69 |
| CHEMBL4298697 | — | — | 1 | 5.52 |
| CHEMBL406654 | CINERENIN | — | 1 | 5.45 |
| CHEMBL1257707 | CNICIN | — | 1 | 5.45 |
| CHEMBL338474 | HELENALIN | — | 1 | 5.37 |
| CHEMBL463559 | MELAMPODIN A | — | 1 | 5.33 |
| CHEMBL273056 | URSINIOLIDE B | — | 1 | 5.28 |
| CHEMBL270307 | STIZOLICIN | — | 1 | 5.24 |
| CHEMBL405877 | ALATOLIDE | — | 1 | 5.24 |
| CHEMBL272221 | CENTAUREPENSIN | — | 1 | 5.22 |
| CHEMBL272222 | — | — | 1 | 5.20 |
| CHEMBL271742 | 1BETA-HYDROXY-8BETA-EPOXYANGELOYLOXYARBUSCULIN B | — | 1 | 5.18 |
| CHEMBL270742 | — | — | 1 | 5.15 |
| CHEMBL206765 | ENHYDRIN | — | 1 | 5.06 |
| CHEMBL409627 | CONFERTIFLORIN | — | 1 | 5.05 |
| CHEMBL485807 | REPIN | — | 1 | 5.03 |
| CHEMBL410453 | — | — | 1 | 5.02 |
| CHEMBL272870 | — | — | 1 | 5.00 |
| CHEMBL270061 | SALONITENOLIDE | — | 1 | 4.99 |
| CHEMBL270297 | LINIFOLIN A | — | 1 | 4.94 |
| CHEMBL259471 | — | — | 1 | 4.75 |
| CHEMBL269841 | GLAUCOLIDE A | — | 1 | 4.68 |
| CHEMBL271958 | GROSSHEIMIN | — | 1 | 4.65 |
| CHEMBL430091 | TATRIDIN B | — | 1 | 4.57 |
| CHEMBL411470 | — | — | 1 | 4.57 |
| CHEMBL411908 | INUCHINENOLIDE C | — | 1 | 4.47 |
| CHEMBL409345 | — | — | 1 | 4.39 |
| CHEMBL270060 | PSILOSTACHYIN A | — | 1 | 4.36 |
| CHEMBL272445 | ASPERILIN | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270551 | URSINIOLIDE A | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL264922 | CINERENIN ACETATE | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL4298697 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL406654 | CINERENIN | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL1257707 | CNICIN | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL338474 | HELENALIN | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL463559 | MELAMPODIN A | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL273056 | URSINIOLIDE B | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL270307 | STIZOLICIN | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL405877 | ALATOLIDE | IC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL272221 | CENTAUREPENSIN | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL272222 | — | IC50 | = | 6320.0 | nM | 5.20 |
| CHEMBL271742 | 1BETA-HYDROXY-8BETA-EPOXYANGELOYLOXYARBUSCULIN B | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL270742 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL206765 | ENHYDRIN | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL409627 | CONFERTIFLORIN | IC50 | = | 8880.0 | nM | 5.05 |
| CHEMBL485807 | REPIN | IC50 | = | 9240.0 | nM | 5.03 |
| CHEMBL410453 | — | IC50 | = | 9520.0 | nM | 5.02 |
| CHEMBL272870 | — | IC50 | = | 10120.0 | nM | 5.00 |
| CHEMBL270061 | SALONITENOLIDE | IC50 | = | 10150.0 | nM | 4.99 |
| CHEMBL270297 | LINIFOLIN A | IC50 | = | 11440.0 | nM | 4.94 |
| CHEMBL259471 | — | IC50 | = | 17730.0 | nM | 4.75 |
| CHEMBL269841 | GLAUCOLIDE A | IC50 | = | 20920.0 | nM | 4.68 |
| CHEMBL271958 | GROSSHEIMIN | IC50 | = | 22180.0 | nM | 4.65 |
| CHEMBL411470 | — | IC50 | = | 26730.0 | nM | 4.57 |
| CHEMBL430091 | TATRIDIN B | IC50 | = | 26970.0 | nM | 4.57 |
| CHEMBL411908 | INUCHINENOLIDE C | IC50 | = | 33470.0 | nM | 4.47 |
| CHEMBL409345 | — | IC50 | = | 40580.0 | nM | 4.39 |
| CHEMBL270060 | PSILOSTACHYIN A | IC50 | = | 44060.0 | nM | 4.36 |
| CHEMBL272445 | ASPERILIN | IC50 | = | 57620.0 | nM | 4.24 |
| CHEMBL273055 | — | IC50 | = | 60080.0 | nM | 4.22 |
| CHEMBL429783 | GEIGERININ | IC50 | = | 73430.0 | nM | 4.13 |
| CHEMBL89311 | SANTAMARIN | IC50 | = | 84930.0 | nM | 4.07 |
| CHEMBL272177 | — | IC50 | > | 209700.0 | nM | - |
| CHEMBL272178 | REYNOSIN | IC50 | = | 271100.0 | nM | - |
| CHEMBL402449 | PULCHELLIN C | IC50 | > | 416200.0 | nM | - |
| CHEMBL406233 | TELEKIN | IC50 | > | 563800.0 | nM | - |
| CHEMBL409039 | SCHKUHRIOLIDE | IC50 | = | 277700.0 | nM | - |
| CHEMBL259254 | SANTONIN | IC50 | > | 568400.0 | nM | - |
| CHEMBL406387 | — | IC50 | > | 488100.0 | nM | - |
| CHEMBL271164 | ARTECANIN | IC50 | > | 134700.0 | nM | - |
| CHEMBL407710 | XERANTOLIDE | IC50 | = | 101400.0 | nM | - |
| CHEMBL490324 | TENULIN | IC50 | = | 361300.0 | nM | - |
| CHEMBL509159 | BURRODIN | IC50 | = | 251400.0 | nM | - |
| CHEMBL406391 | 1,10-EPOXYCOSTUNOLIDE | IC50 | = | 121300.0 | nM | - |
| CHEMBL401149 | PARTHENIN | IC50 | = | 129300.0 | nM | - |
| CHEMBL248564 | CORONOPILIN | IC50 | = | 248900.0 | nM | - |
| CHEMBL410051 | — | IC50 | > | 413000.0 | nM | - |
| CHEMBL429762 | 11BETA,13-DIHYDRO-PARTHENOLIDE | IC50 | > | 399500.0 | nM | - |
| CHEMBL271959 | — | IC50 | > | 454000.0 | nM | - |