Compound Detail
CHEMBL270060
PSILOSTACHYIN A Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL270060 |
| Name | PSILOSTACHYIN A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IRPFOXRBPHCCTG-JISBIHODSA-N |
5
Targets
6
Activities
2
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
280.3
MW (Da)
1.34
ALogP
5
HBA
1
HBD
72.8
PSA (Ų)
0.54
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.38
IC50 3 meas. best 5.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leishmania mexicana CHEMBL612880 | EC50 | 6.38 | 6.38 | 420.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | EC50 | 5.37 | 5.135 | 4300.0 | 2 |
| Prostaglandin G/H synthase 2 CHEMBL230 | IC50 | 5.34 | 5.34 | 4600.0 | 1 |
| Platelet CHEMBL4296519 | IC50 | 4.36 | 4.36 | 44060.0 | 1 |
| Transcriptional activator Myb CHEMBL2380186 | IC50 | 4.3 | 4.3 | 50003.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leishmania mexicana | EC50 | = | 420.0 | nM | 6.38 | Antileishmanial activity against Leishmania mexicana promastigotes assessed as p... | 30234295 |
| Trypanosoma cruzi | EC50 | = | 4300.0 | nM | 5.37 | Antitrypanosomal activity against epimastigote form of Trypanosoma cruzi assesse... | 30234295 |
| Prostaglandin G/H synthase 2 | IC50 | = | 4600.0 | nM | 5.34 | Inhibition of COX2 | 16038536 |
| Trypanosoma cruzi | EC50 | = | 12500.0 | nM | 4.9 | Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi asses... | 30234295 |
| Platelet | IC50 | = | 44060.0 | nM | 4.36 | Inhibition of serotonin release in bovine platelets | 18271521 |
| Transcriptional activator Myb | IC50 | = | 50003.45 | nM | 4.3 | Inhibition of c-Myb-induced mim-1 gene expression in doxycyclin-treated chicken ... | 23501116 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18443111 | 10.1128/aac.01630-07 | Trypanosoma cruzi | 5 |
| 30234295 | 10.1021/acs.jnatprod.8b00159 | Trypanosoma cruzi | 4 |
| 23501116 | 10.1016/j.ejmech.2013.02.018 | Transcriptional activator Myb | 2 |
| 18271521 | 10.1021/jm701318x | Platelet | 1 |
| 16038536 | 10.1021/np049655u | Prostaglandin G/H synthase 2 | 1 |
| 18443111 | 10.1128/aac.01630-07 | Leishmania mexicana | 1 |
| 18443111 | 10.1128/aac.01630-07 | ADMET | 1 |
| 18443111 | 10.1128/aac.01630-07 | Unchecked | 1 |
| 21752638 | 10.1016/j.bmcl.2011.06.037 | NON-PROTEIN TARGET | 1 |
| 23501116 | 10.1016/j.ejmech.2013.02.018 | ADMET | 1 |
| 30234295 | 10.1021/acs.jnatprod.8b00159 | Leishmania mexicana | 1 |
Data from ChEMBL 36 via Core Engine