Assay Detail
Functional
CHEMBL952617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol-resistant human Jurkat SBR2 mutant cells proliferation after 18 hrs by MTT assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.34 | 5.54 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67166 | SPHINGOSINE | — | 1 | 5.54 |
| CHEMBL448741 | DIHYDROSPINGOSINE | — | 1 | 5.43 |
| CHEMBL236036 | PHYTOSPHINGOSINE | — | 1 | 5.28 |
| CHEMBL268745 | — | — | 1 | 5.11 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67166 | SPHINGOSINE | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL448741 | DIHYDROSPINGOSINE | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL236036 | PHYTOSPHINGOSINE | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL268745 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL44657 | ETOPOSIDE | Activity | - | — | - |