Assay Detail
Binding
CHEMBL953205
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Inhibition of c-Met by HTRF assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.94 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494985 | — | — | 1 | 9.00 |
| CHEMBL497118 | — | — | 1 | 9.00 |
| CHEMBL523386 | — | — | 1 | 8.70 |
| CHEMBL523413 | — | — | 1 | 8.52 |
| CHEMBL494984 | — | — | 1 | 8.52 |
| CHEMBL497117 | — | — | 1 | 8.40 |
| CHEMBL494979 | — | — | 1 | 8.40 |
| CHEMBL498769 | — | — | 1 | 8.22 |
| CHEMBL494983 | — | — | 1 | 8.22 |
| CHEMBL494793 | — | — | 1 | 8.15 |
| CHEMBL494630 | — | — | 1 | 8.15 |
| CHEMBL522196 | — | — | 1 | 8.05 |
| CHEMBL496102 | AMG-208 | 2.0 | 1 | 8.05 |
| CHEMBL505896 | — | — | 1 | 8.00 |
| CHEMBL497968 | — | — | 1 | 7.92 |
| CHEMBL497119 | — | — | 1 | 7.54 |
| CHEMBL494794 | — | — | 1 | 7.17 |
| CHEMBL495898 | — | — | 1 | 6.92 |
| CHEMBL495899 | — | — | 1 | 6.21 |
| CHEMBL496101 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494985 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL497118 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL523386 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL523413 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL494984 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL497117 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL494979 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL498769 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL494983 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL494793 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL494630 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL522196 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL496102 | AMG-208 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL505896 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL497968 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL497119 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL494794 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL495898 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL495899 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL496101 | — | IC50 | = | 2100.0 | nM | 5.68 |