Compound Detail
CHEMBL494793
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Basic Information
| ChEMBL ID | CHEMBL494793 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WBVUSUBFBIAVDP-UHFFFAOYSA-N |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
401.4
MW (Da)
4.07
ALogP
7
HBA
0
HBD
74.4
PSA (Ų)
0.44
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.15
Ki 1 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.15 | 8.0 | 7.0 | 3 |
| Hepatocyte growth factor receptor CHEMBL3717 | Ki | 8.15 | 8.15 | 7.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 7.0 | nM | 8.15 | Inhibition of c-Met by HTRF assay | 18426196 |
| Hepatocyte growth factor receptor | IC50 | = | 7.0 | nM | 8.15 | Inhibition of human c-MET | 21641696 |
| Hepatocyte growth factor receptor | Ki | = | 7.0 | nM | 8.15 | In Vitro Assay: A PCR product covering residues 1058-1365 of c-Met (c-Met kinase... | - |
| Hepatocyte growth factor receptor | IC50 | = | 20.0 | nM | 7.7 | Inhibition of HGF-mediated c-Met phosphorylation in serum-starved human PC2 cell... | 18426196 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18426196 | 10.1021/jm800043g | Hepatocyte growth factor receptor | 2 |
| 21641696 | 10.1016/j.ejmech.2011.05.031 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine