Assay Detail
Binding
CHEMBL953206
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Inhibition of HGF-mediated c-Met phosphorylation in serum-starved human PC2 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.83 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523413 | — | — | 1 | 8.70 |
| CHEMBL497118 | — | — | 1 | 8.70 |
| CHEMBL494985 | — | — | 1 | 8.70 |
| CHEMBL494984 | — | — | 1 | 8.52 |
| CHEMBL523386 | — | — | 1 | 8.22 |
| CHEMBL494979 | — | — | 1 | 8.15 |
| CHEMBL494630 | — | — | 1 | 7.85 |
| CHEMBL494983 | — | — | 1 | 7.80 |
| CHEMBL494793 | — | — | 1 | 7.70 |
| CHEMBL522196 | — | — | 1 | 7.58 |
| CHEMBL497117 | — | — | 1 | 7.54 |
| CHEMBL497968 | — | — | 1 | 7.38 |
| CHEMBL496102 | AMG-208 | 2.0 | 1 | 7.34 |
| CHEMBL497119 | — | — | 1 | 6.88 |
| CHEMBL494794 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523413 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL497118 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL494985 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL494984 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL523386 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL494979 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL494630 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL494983 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL494793 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL522196 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL497117 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL497968 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL496102 | AMG-208 | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL497119 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL494794 | — | IC50 | = | 400.0 | nM | 6.40 |