Compound Detail
CHEMBL497119
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Basic Information
| ChEMBL ID | CHEMBL497119 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DBJXJFMUTHNNGW-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
292.3
MW (Da)
2.68
ALogP
6
HBA
1
HBD
76.5
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 7.54 | 7.32 | 29.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 29.0 | nM | 7.54 | Inhibition of c-Met by HTRF assay | 18426196 |
| Hepatocyte growth factor receptor | IC50 | = | 29.0 | nM | 7.54 | Inhibition of human c-MET | 21641696 |
| Hepatocyte growth factor receptor | IC50 | = | 132.0 | nM | 6.88 | Inhibition of HGF-mediated c-Met phosphorylation in serum-starved human PC2 cell... | 18426196 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18426196 | 10.1021/jm800043g | Hepatocyte growth factor receptor | 2 |
| 21641696 | 10.1016/j.ejmech.2011.05.031 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine