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Assay Detail

CHEMBL959247

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Functional
Cytotoxicity against human BT474 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BT-474
Confidence 1 — Organism
Curated By Autocuration

Target

BT-474 (CHEMBL614529)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors.
Seefeld MA, Rouse MB, McNulty KC, Sun L, Wang J, Yamashita DS, Luengo JI, Zhang S, Minthorn EA, Concha NO, Heerding DA.
Bioorg Med Chem Lett (2009) 19 : 2244 -2248
PubMed 19285393 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.25 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL520788 1 7.22
CHEMBL482536 1 7.22
CHEMBL498052 1 6.92
CHEMBL469590 1 6.70
CHEMBL470597 1 6.64
CHEMBL523586 1 6.62
CHEMBL496690 1 6.30
CHEMBL482537 1 5.92
CHEMBL524998 1 5.72
CHEMBL498051 1 5.64
CHEMBL470598 1 5.58
CHEMBL512135 1 5.40
CHEMBL513728 1 5.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL520788 IC50 = 60.0 nM 7.22
CHEMBL482536 IC50 = 60.0 nM 7.22
CHEMBL498052 IC50 = 120.0 nM 6.92
CHEMBL469590 IC50 = 200.0 nM 6.70
CHEMBL470597 IC50 = 230.0 nM 6.64
CHEMBL523586 IC50 = 240.0 nM 6.62
CHEMBL496690 IC50 = 500.0 nM 6.30
CHEMBL482537 IC50 = 1200.0 nM 5.92
CHEMBL524998 IC50 = 1900.0 nM 5.72
CHEMBL498051 IC50 = 2300.0 nM 5.64
CHEMBL470598 IC50 = 2600.0 nM 5.58
CHEMBL512135 IC50 = 4000.0 nM 5.40
CHEMBL513728 IC50 = 4500.0 nM 5.35