Compound Detail
CHEMBL498051
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Basic Information
| ChEMBL ID | CHEMBL498051 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CYBHYLPLXYMGPJ-ZDUSSCGKSA-N |
6
Targets
6
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
456.4
MW (Da)
3.75
ALogP
5
HBA
3
HBD
96.7
PSA (Ų)
0.41
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.12
Ki 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | Ki | 8.7 | 8.7 | 2.0 | 1 |
| RAC-beta serine/threonine-protein kinase CHEMBL2431 | Ki | 7.4 | 7.4 | 40.0 | 1 |
| LNCaP CHEMBL612518 | IC50 | 6.12 | 6.12 | 750.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.72 | 5.72 | 1900.0 | 1 |
| BT-474 CHEMBL614529 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
| HFF CHEMBL614071 | IC50 | 5.44 | 5.44 | 3600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | Ki | = | 2.0 | nM | 8.7 | Inhibition of AKT1 | 19285393 |
| RAC-beta serine/threonine-protein kinase | Ki | = | 40.0 | nM | 7.4 | Inhibition of AKT2 | 19285393 |
| LNCaP | IC50 | = | 750.0 | nM | 6.12 | Cytotoxicity against human LNCAP cells | 19285393 |
| Unchecked | IC50 | = | 1900.0 | nM | 5.72 | Inhibition of AKT-mediated GSK3-beta phosphorylation in human BT474 cells by mec... | 19285393 |
| BT-474 | IC50 | = | 2300.0 | nM | 5.64 | Cytotoxicity against human BT474 cells | 19285393 |
| HFF | IC50 | = | 3600.0 | nM | 5.44 | Cytotoxicity against human HFF cells | 19285393 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19285393 | 10.1016/j.bmcl.2009.02.094 | RAC-alpha serine/threonine-protein kinase | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | Unchecked | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | RAC-gamma serine/threonine-protein kinase | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | BT-474 | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | LNCaP | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | HFF | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | RAC-beta serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine