Compound Detail
CHEMBL482537
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NC[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1
Basic Information
| ChEMBL ID | CHEMBL482537 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VEQOEEQRVZZGQZ-AWEZNQCLSA-N |
7
Targets
9
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
523.4
MW (Da)
5.37
ALogP
4
HBA
3
HBD
83.8
PSA (Ų)
0.32
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 8.7
Ki 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | Ki | 8.7 | 8.7 | 2.0 | 1 |
| RAC-gamma serine/threonine-protein kinase CHEMBL4816 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| RAC-beta serine/threonine-protein kinase CHEMBL2431 | Ki | 7.8 | 7.8 | 16.0 | 1 |
| RAC-beta serine/threonine-protein kinase CHEMBL2431 | IC50 | 7.1 | 7.1 | 79.0 | 1 |
| LNCaP CHEMBL612518 | IC50 | 6.36 | 6.36 | 440.0 | 1 |
| BT-474 CHEMBL614529 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| HFF CHEMBL614071 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 2.0 | nM | 8.7 | Inhibition of AKT1 | 19285393 |
| RAC-alpha serine/threonine-protein kinase | Ki | = | 2.0 | nM | 8.7 | Inhibition of AKT1 | 19285393 |
| RAC-gamma serine/threonine-protein kinase | IC50 | = | 3.0 | nM | 8.52 | Inhibition of AKT3 | 19285393 |
| RAC-beta serine/threonine-protein kinase | Ki | = | 16.0 | nM | 7.8 | Inhibition of AKT2 | 19285393 |
| RAC-beta serine/threonine-protein kinase | IC50 | = | 79.0 | nM | 7.1 | Inhibition of AKT2 | 19285393 |
| LNCaP | IC50 | = | 440.0 | nM | 6.36 | Cytotoxicity against human LNCAP cells | 19285393 |
| BT-474 | IC50 | = | 1200.0 | nM | 5.92 | Cytotoxicity against human BT474 cells | 19285393 |
| HFF | IC50 | = | 1300.0 | nM | 5.89 | Cytotoxicity against human HFF cells | 19285393 |
| Unchecked | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of AKT-mediated GSK3-beta phosphorylation in human BT474 cells by mec... | 19285393 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19285393 | 10.1016/j.bmcl.2009.02.094 | RAC-alpha serine/threonine-protein kinase | 2 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | RAC-beta serine/threonine-protein kinase | 2 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | Unchecked | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | RAC-gamma serine/threonine-protein kinase | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | BT-474 | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | LNCaP | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | HFF | 1 |
| - | 10.6019/CHEMBL3988181 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine