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Assay Detail

CHEMBL964535

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A375 cells after 96 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A-375
Confidence 1 — Organism
Curated By Autocuration

Target

A-375 (CHEMBL613859)
Type CELL-LINE
Organism Homo sapiens

Publication

In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivatives.
Moarbess G, Deleuze-Masquefa C, Bonnard V, Gayraud-Paniagua S, Vidal JR, Bressolle F, Pinguet F, Bonnet PA.
Bioorg Med Chem (2008) 16 : 6601 -6610
PubMed 18513976 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.50 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488644 1 5.80
CHEMBL487453 1 5.63
CHEMBL487454 1 4.62
CHEMBL488482 1 4.50
CHEMBL519409 1 4.32
CHEMBL519408 1 4.18
CHEMBL1282 IMIQUIMOD 4.0 1 4.15
CHEMBL454343 1 4.11
CHEMBL487455 1 4.10
CHEMBL506332 1 4.07
CHEMBL454953 1 4.00
CHEMBL511023 1 -
CHEMBL452296 1 -
CHEMBL503970 1 -
CHEMBL452816 1 -
CHEMBL508967 1 -
CHEMBL549386 FOTEMUSTINE 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488644 IC50 = 1570.0 nM 5.80
CHEMBL487453 IC50 = 2350.0 nM 5.63
CHEMBL487454 IC50 = 24000.0 nM 4.62
CHEMBL488482 IC50 = 31600.0 nM 4.50
CHEMBL519409 IC50 = 47800.0 nM 4.32
CHEMBL519408 IC50 = 66300.0 nM 4.18
CHEMBL1282 IMIQUIMOD IC50 = 70300.0 nM 4.15
CHEMBL454343 IC50 = 78600.0 nM 4.11
CHEMBL487455 IC50 = 80100.0 nM 4.10
CHEMBL506332 IC50 = 85300.0 nM 4.07
CHEMBL454953 IC50 = 100000.0 nM 4.00
CHEMBL511023 IC50 > 400000.0 nM -
CHEMBL452296 IC50 = 329000.0 nM -
CHEMBL503970 IC50 = 121000.0 nM -
CHEMBL452816 IC50 > 400000.0 nM -
CHEMBL508967 IC50 = 101000.0 nM -
CHEMBL549386 FOTEMUSTINE IC50 = 173000.0 nM -