Assay Detail
ADMET
CHEMBL972070
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Inhibition of CYP3A4
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.87 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481839 | ESCHOLTZINE | — | 1 | 4.87 |
| CHEMBL226335 | RUTIN | 3.0 | 1 | - |
| CHEMBL538357 | CALIFORNIDINE | — | 1 | - |
| CHEMBL486179 | PROTOPINE | — | 1 | - |
| CHEMBL258394 | NARCISSIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481839 | ESCHOLTZINE | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL226335 | RUTIN | IC50 | > | 80000.0 | nM | - |
| CHEMBL538357 | CALIFORNIDINE | IC50 | > | 80000.0 | nM | - |
| CHEMBL486179 | PROTOPINE | IC50 | > | 80000.0 | nM | - |
| CHEMBL258394 | NARCISSIN | IC50 | > | 80000.0 | nM | - |