Assay Detail
Functional
CHEMBL978312
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Antiinflammatory activity in human PMN assessed as inhibition of Phorbol-12-myristate-13-acetate-induced ROS production
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-inflammatory neolignans from Piper kadsura.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.08 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526286 | PIPERKADSIN A | — | 1 | 5.37 |
| CHEMBL497039 | PIPERLACTAM S | — | 1 | 5.16 |
| CHEMBL64286 | N-P-COUMAROYL TYRAMINE | — | 1 | 5.08 |
| CHEMBL498295 | PIPERKADSIN B | — | 1 | 4.91 |
| CHEMBL498296 | FUTOQUINOL | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526286 | PIPERKADSIN A | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL497039 | PIPERLACTAM S | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL64286 | N-P-COUMAROYL TYRAMINE | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL498295 | PIPERKADSIN B | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL498296 | FUTOQUINOL | IC50 | = | 13100.0 | nM | 4.88 |