Assay Detail
Binding
CHEMBL980054
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Inhibition of CSF1R
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.89 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461365 | — | — | 1 | 8.52 |
| CHEMBL517437 | — | — | 1 | 8.52 |
| CHEMBL461573 | — | — | 1 | 8.52 |
| CHEMBL459674 | — | — | 1 | 8.52 |
| CHEMBL444671 | — | — | 1 | 8.40 |
| CHEMBL462133 | — | — | 1 | 8.40 |
| CHEMBL459471 | — | — | 1 | 8.30 |
| CHEMBL461572 | — | — | 1 | 8.30 |
| CHEMBL462128 | — | — | 1 | 8.22 |
| CHEMBL459675 | — | — | 1 | 8.15 |
| CHEMBL462130 | — | — | 1 | 8.15 |
| CHEMBL462132 | — | — | 1 | 8.15 |
| CHEMBL459470 | — | — | 1 | 8.10 |
| CHEMBL461952 | — | — | 1 | 8.05 |
| CHEMBL461950 | — | — | 1 | 8.00 |
| CHEMBL454876 | — | — | 1 | 8.00 |
| CHEMBL461574 | — | — | 1 | 8.00 |
| CHEMBL513588 | — | — | 1 | 7.96 |
| CHEMBL507803 | — | — | 1 | 7.96 |
| CHEMBL1567 | SUNITINIB MALATE | 4.0 | 1 | 7.92 |
| CHEMBL472342 | — | — | 1 | 7.89 |
| CHEMBL461951 | — | — | 1 | 7.85 |
| CHEMBL516813 | — | — | 1 | 7.80 |
| CHEMBL510386 | — | — | 1 | 7.80 |
| CHEMBL512385 | — | — | 1 | 7.60 |
| CHEMBL472343 | — | — | 1 | 7.51 |
| CHEMBL454105 | — | — | 1 | 7.50 |
| CHEMBL454104 | — | — | 1 | 7.43 |
| CHEMBL454616 | — | — | 1 | 7.05 |
| CHEMBL472512 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461365 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL517437 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL461573 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL459674 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL444671 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL462133 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL459471 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL461572 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL462128 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL459675 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL462130 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL462132 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL459470 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL461952 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL454876 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL461574 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL461950 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL513588 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL507803 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1567 | SUNITINIB MALATE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL472342 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL461951 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL510386 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL516813 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL512385 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL472343 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL454105 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL454104 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL454616 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL472512 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL469883 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL461366 | — | IC50 | > | 50000.0 | nM | - |