Assay Detail
Functional
CHEMBL980159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
38
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.72 | 5.30 |
| Activity | 14 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75978 | 5-DEMETHYLNOBILETIN | — | 1 | 5.30 |
| CHEMBL77993 | 3,5,6,7,8,3',4'-HEPTAMETHOXYFLAVONE | — | 1 | 5.30 |
| CHEMBL226507 | SINENSETIN | — | 1 | 5.10 |
| CHEMBL76447 | NOBILETIN | — | 1 | 5.00 |
| CHEMBL422237 | — | — | 1 | 5.00 |
| CHEMBL451707 | — | — | 1 | 4.80 |
| CHEMBL28 | APIGENIN | — | 1 | 4.70 |
| CHEMBL370963 | — | — | 1 | 4.70 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.70 |
| CHEMBL214321 | CHRYSOERIOL | — | 1 | 4.66 |
| CHEMBL312163 | RHAMNETIN | — | 1 | 4.66 |
| CHEMBL243664 | ACACETIN | — | 1 | 4.66 |
| CHEMBL75349 | TETRAMETHYLSCUTELLAREIN | — | 1 | 4.66 |
| CHEMBL252339 | — | — | 1 | 4.60 |
| CHEMBL73930 | TANGERETIN | — | 1 | 4.52 |
| CHEMBL163316 | 3-O-METHYLQUERCETIN | — | 1 | 4.33 |
| CHEMBL452488 | LIMOCITRIN | — | 1 | 4.17 |
| CHEMBL451709 | TAMARAXETIN | — | 1 | 4.16 |
| CHEMBL309490 | GALANGIN | — | 1 | - |
| CHEMBL206452 | CATECHIN | — | 1 | - |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | - |
| CHEMBL294009 | FLAVONOL | — | 1 | - |
| CHEMBL399121 | HESPERETIN | 0.5 | 1 | - |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | - |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
| CHEMBL117 | CHRYSIN | — | 1 | - |
| CHEMBL31574 | FISETIN | 2.0 | 1 | - |
| CHEMBL449317 | HESPERIDIN | 3.0 | 1 | - |
| CHEMBL274318 | FLAVANONE | — | 1 | - |
| CHEMBL8996 | ERIODICTYOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75978 | 5-DEMETHYLNOBILETIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL77993 | 3,5,6,7,8,3',4'-HEPTAMETHOXYFLAVONE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL226507 | SINENSETIN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL76447 | NOBILETIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL422237 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL451707 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL28 | APIGENIN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL370963 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL214321 | CHRYSOERIOL | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL312163 | RHAMNETIN | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL243664 | ACACETIN | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL75349 | TETRAMETHYLSCUTELLAREIN | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL252339 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL73930 | TANGERETIN | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL163316 | 3-O-METHYLQUERCETIN | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL452488 | LIMOCITRIN | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL451709 | TAMARAXETIN | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL231884 | DIOSMIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL446246 | NARIRUTIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL451532 | NARINGIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL275638 | FLAVONE | IC50 | = | 166000.0 | nM | - |
| CHEMBL50 | QUERCETIN | IC50 | = | 120000.0 | nM | - |
| CHEMBL164 | MYRICETIN | Activity | - | — | - | |
| CHEMBL3143891 | — | Activity | - | — | - | |
| CHEMBL253570 | GOSSYPETIN | Activity | - | — | - | |
| CHEMBL8996 | ERIODICTYOL | Activity | - | — | - | |
| CHEMBL274318 | FLAVANONE | Activity | - | — | - | |
| CHEMBL449317 | HESPERIDIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL31574 | FISETIN | Activity | - | — | - | |
| CHEMBL117 | CHRYSIN | Activity | - | — | - | |
| CHEMBL583912 | (-)-EPICATECHIN | Activity | - | — | - | |
| CHEMBL8260 | BAICALEIN | Activity | - | — | - | |
| CHEMBL399121 | HESPERETIN | Activity | - | — | - | |
| CHEMBL294009 | FLAVONOL | Activity | - | — | - | |
| CHEMBL276915 | 7-HYDROXYFLAVONE | Activity | - | — | - | |
| CHEMBL206452 | CATECHIN | Activity | - | — | - | |
| CHEMBL309490 | GALANGIN | Activity | - | — | - |