Assay Detail
Binding
CHEMBL985804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGP39653 from NMDA receptor in Sprague-Dawley rat brain membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.97 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 7.16 |
| CHEMBL507082 | CRIBRONIC ACID | — | 1 | 7.08 |
| CHEMBL509090 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL507082 | CRIBRONIC ACID | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL509090 | — | IC50 | = | 214.0 | nM | 6.67 |