Assay Detail
Functional
CHEMBL985929
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Anticancer activity against human HL60 cells by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.53 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.75 |
| CHEMBL449370 | — | — | 1 | 7.30 |
| CHEMBL24704 | — | — | 1 | 7.16 |
| CHEMBL507226 | — | — | 1 | 7.00 |
| CHEMBL506075 | — | — | 1 | 7.00 |
| CHEMBL447991 | — | — | 1 | 6.80 |
| CHEMBL505378 | — | — | 1 | 6.60 |
| CHEMBL284863 | — | — | 1 | 6.57 |
| CHEMBL450980 | — | — | 1 | 6.40 |
| CHEMBL510943 | — | — | 1 | 6.11 |
| CHEMBL504137 | — | — | 1 | 5.98 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 5.62 |
| CHEMBL508096 | — | — | 1 | 4.55 |
| CHEMBL446048 | — | — | 1 | - |
| CHEMBL445951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL449370 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL24704 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL507226 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL506075 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL447991 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL505378 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL284863 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL450980 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL510943 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL504137 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL508096 | — | IC50 | = | 28140.0 | nM | 4.55 |
| CHEMBL446048 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL445951 | — | IC50 | > | 100000.0 | nM | - |