Assay Detail
ADMET
CHEMBL989847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP2D6 expressed in baculovirus-infected insect microsomes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.30 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456390 | — | — | 1 | 4.30 |
| CHEMBL460178 | — | — | 1 | - |
| CHEMBL462093 | — | — | 1 | - |
| CHEMBL448743 | — | — | 1 | - |
| CHEMBL499007 | — | — | 1 | - |
| CHEMBL62811 | — | — | 1 | - |
| CHEMBL446083 | — | — | 1 | - |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456390 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL460178 | — | IC50 | < | 200000.0 | nM | - |
| CHEMBL462093 | — | IC50 | = | 171000.0 | nM | - |
| CHEMBL448743 | — | IC50 | < | 200000.0 | nM | - |
| CHEMBL499007 | — | IC50 | < | 200000.0 | nM | - |
| CHEMBL62811 | — | IC50 | = | 171000.0 | nM | - |
| CHEMBL446083 | — | IC50 | < | 200000.0 | nM | - |
| CHEMBL1294 | QUINIDINE | IC50 | = | 14000.0 | nM | - |