Assay Detail
Binding
CHEMBL993563
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Inhibition of rat intestinal brush border membrane isomaltase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.26 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 6.80 |
| CHEMBL476960 | VOGLIBOSE | 4.0 | 1 | 6.80 |
| CHEMBL478209 | — | — | 1 | 6.22 |
| CHEMBL501355 | — | — | 1 | 6.16 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 5.92 |
| CHEMBL222396 | VALIOLAMINE | — | 1 | 5.68 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | - |
| CHEMBL108084 | FAGOMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL476960 | VOGLIBOSE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL478209 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL501355 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1561 | MIGLITOL | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL222396 | VALIOLAMINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 380000.0 | nM | - |
| CHEMBL108084 | FAGOMINE | IC50 | = | 460000.0 | nM | - |