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Assay Detail

CHEMBL993750

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Marine natural products as novel antioxidant prototypes.
Takamatsu S, Hodges TW, Rajbhandari I, Gerwick WH, Hamann MT, Nagle DG.
J Nat Prod (2003) 66 : 605 -608
PubMed 12762791 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.89 5.40
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL448798 CYMOPOL 1 5.40
CHEMBL460434 AVRAINVILLEOL 1 5.21
CHEMBL196 ASCORBIC ACID 4.0 1 5.01
CHEMBL46198 ARAGILAMIDE 1 4.96
CHEMBL466369 HORMOTHAMNIONE DIACETATE 1 4.74
CHEMBL157844 PUUPEHENONE 1 4.57
CHEMBL466370 1 4.31
CHEMBL504569 1 -
CHEMBL3989727 VITAMIN E 4.0 1 -
CHEMBL513477 HORMOTHAMNIONE 1 -
CHEMBL505177 SCYTONEMIN 1 -
CHEMBL301307 ISOAAPTAMINE 1 -
CHEMBL234658 AAPTAMINE 1 -
CHEMBL451860 1 -
CHEMBL463075 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL448798 CYMOPOL IC50 = 4000.0 nM 5.40
CHEMBL460434 AVRAINVILLEOL IC50 = 6100.0 nM 5.21
CHEMBL196 ASCORBIC ACID IC50 = 9700.0 nM 5.01
CHEMBL46198 ARAGILAMIDE IC50 = 11000.0 nM 4.96
CHEMBL466369 HORMOTHAMNIONE DIACETATE IC50 = 18300.0 nM 4.74
CHEMBL157844 PUUPEHENONE IC50 = 27000.0 nM 4.57
CHEMBL466370 IC50 = 49000.0 nM 4.31
CHEMBL504569 Activity - -
CHEMBL3989727 VITAMIN E IC50 = 255000.0 nM -
CHEMBL513477 HORMOTHAMNIONE IC50 > 31000.0 nM -
CHEMBL505177 SCYTONEMIN IC50 > 23000.0 nM -
CHEMBL301307 ISOAAPTAMINE IC50 > 55000.0 nM -
CHEMBL234658 AAPTAMINE IC50 > 55000.0 nM -
CHEMBL451860 IC50 = 209000.0 nM -
CHEMBL463075 IC50 > 14600.0 nM -