Assay Detail
Functional
CHEMBL999220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimigraine activity in bovine citreated platelet assessed as inhibition of [14C]serotonin release after 6 mins by scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A bioassay for inhibition of serotonin release from bovine platelets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.01 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298697 | — | — | 1 | 5.52 |
| CHEMBL1257707 | CNICIN | — | 1 | 5.45 |
| CHEMBL89311 | SANTAMARIN | — | 1 | 4.07 |
| CHEMBL1280 | VERAPAMIL HYDROCHLORIDE | 4.0 | 1 | - |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | 4.0 | 1 | - |
| CHEMBL429762 | 11BETA,13-DIHYDRO-PARTHENOLIDE | — | 1 | - |
| CHEMBL406391 | 1,10-EPOXYCOSTUNOLIDE | — | 1 | - |
| CHEMBL272178 | REYNOSIN | — | 1 | - |
| CHEMBL259254 | SANTONIN | -1.0 | 1 | - |
| CHEMBL137803 | ISOALANTOLACTONE | — | 1 | - |
| CHEMBL401149 | PARTHENIN | — | 1 | - |
| CHEMBL271164 | ARTECANIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298697 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL1257707 | CNICIN | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL89311 | SANTAMARIN | IC50 | = | 84930.0 | nM | 4.07 |
| CHEMBL1280 | VERAPAMIL HYDROCHLORIDE | IC50 | = | 577500.0 | nM | - |
| CHEMBL1671 | PROPRANOLOL HYDROCHLORIDE | IC50 | > | 939800.0 | nM | - |
| CHEMBL429762 | 11BETA,13-DIHYDRO-PARTHENOLIDE | IC50 | > | 399500.0 | nM | - |
| CHEMBL406391 | 1,10-EPOXYCOSTUNOLIDE | IC50 | = | 121300.0 | nM | - |
| CHEMBL272178 | REYNOSIN | IC50 | = | 271100.0 | nM | - |
| CHEMBL259254 | SANTONIN | IC50 | > | 568400.0 | nM | - |
| CHEMBL137803 | ISOALANTOLACTONE | IC50 | > | 516500.0 | nM | - |
| CHEMBL401149 | PARTHENIN | IC50 | = | 129300.0 | nM | - |
| CHEMBL271164 | ARTECANIN | IC50 | > | 134700.0 | nM | - |