Compound Detail
CHEMBL11508
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Basic Information
| ChEMBL ID | CHEMBL11508 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HXALHRWESQWBPV-MHMBTURYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
421.4
MW (Da)
5.71
ALogP
4
HBA
2
HBD
87.5
PSA (Ų)
0.31
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.25
Kd 1 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor CHEMBL2094254 | Kd | 7.58 | 7.58 | 26.0 | 1 |
| Cavia porcellus CHEMBL369 | IC50 | 7.25 | 7.25 | 56.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor | Kd | = | 26.0 | nM | 7.58 | Displacement of [3H]LTD4 from Cysteinyl leukotriene D4 receptor in guinea pig lu... | 9089329 |
| Cavia porcellus | IC50 | = | 56.0 | nM | 7.25 | Inhibition of LTD4 induced contraction of guinea pig ileum | 9089329 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9089329 | 10.1021/jm960628d | Cavia porcellus | 3 |
| 9089329 | 10.1021/jm960628d | Cysteinyl leukotriene receptor | 1 |
Data from ChEMBL 36 via Core Engine