Assay Detail
Functional
CHEMBL687396
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Inhibition of LTD4 induced contraction of guinea pig ileum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of carboxylated chalcones: a novel series of CysLT1 (LTD4) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.00 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11870 | — | — | 1 | 7.64 |
| CHEMBL12018 | — | — | 1 | 7.34 |
| CHEMBL11508 | — | — | 1 | 7.25 |
| CHEMBL268269 | — | — | 1 | 6.72 |
| CHEMBL11899 | — | — | 1 | 6.62 |
| CHEMBL11905 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11870 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL12018 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL11508 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL268269 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL11899 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL11905 | — | IC50 | = | 360.0 | nM | 6.44 |