Compound Detail
CHEMBL1256565
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Basic Information
| ChEMBL ID | CHEMBL1256565 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ASHFKBMVCDTQQO-VHDGCEQUSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
240.3
MW (Da)
2.93
ALogP
2
HBA
1
HBD
37.9
PSA (Ų)
0.90
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 8.48 | 8.48 | 3.3 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 8.01 | 8.01 | 9.8 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 7.99 | 7.99 | 10.2 | 1 |
| Alpha-1B adrenergic receptor CHEMBL232 | Ki | 7.4 | 7.4 | 39.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Ki | = | 3.311 | nM | 8.48 | Displacement of [3H]-RX821002 from human adrenergic alpha2A receptor expressed i... | 20809632 |
| Alpha-2B adrenergic receptor | Ki | = | 9.772 | nM | 8.01 | Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed i... | 20809632 |
| Alpha-2C adrenergic receptor | Ki | = | 10.23 | nM | 7.99 | Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed ... | 20809632 |
| Alpha-1B adrenergic receptor | Ki | = | 39.81 | nM | 7.4 | Displacement of [3H]-prazosin from human adrenergic alpha-1b receptor expressed ... | 20809632 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20809632 | 10.1021/jm1006269 | Mus musculus | 3 |
| 20809632 | 10.1021/jm1006269 | Alpha-2A adrenergic receptor | 2 |
| 20809632 | 10.1021/jm1006269 | Alpha-2C adrenergic receptor | 1 |
| 20809632 | 10.1021/jm1006269 | Alpha-2B adrenergic receptor | 1 |
| 20809632 | 10.1021/jm1006269 | Alpha-1B adrenergic receptor | 1 |
Data from ChEMBL 36 via Core Engine