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Compound Detail

CHEMBL1302109

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O=C(c1cc(COc2ccc3ncccc3c2)on1)N1CCCCCC1

Basic Information

ChEMBL ID CHEMBL1302109
Phase Preclinical
Structure Type MOL
InChI Key HULSBULGPLDAJB-UHFFFAOYSA-N
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

351.4
MW (Da)
3.82
ALogP
5
HBA
0
HBD
68.5
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H21N3O3
MW 351.41
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -1.80

Activity Summary

IC50 4 meas. best 5.95
EC50 1 meas. best 5.73

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.95 5.84 1130.0 2
HEK293
CHEMBL614818
EC50 5.73 5.73 1850.0 1
HEK293
CHEMBL614818
IC50 5.24 5.06 5760.5 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine