Compound Detail
CHEMBL134423
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Basic Information
| ChEMBL ID | CHEMBL134423 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SUBRNIMHHUWIJU-UHFFFAOYSA-N |
3
Targets
8
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
434.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A CHEMBL322 | IC50 | 8.7 | 8.155 | 2.0 | 4 |
| Adrenergic receptor alpha-1 CHEMBL2094251 | IC50 | 7.07 | 7.035 | 86.0 | 2 |
| D(2) dopamine receptor CHEMBL217 | IC50 | 7.0 | 6.925 | 100.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | IC50 | = | 2.0 | nM | 8.7 | In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical memb... | - |
| 5-hydroxytryptamine receptor 2A | IC50 | = | 3.0 | nM | 8.52 | In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical memb... | - |
| 5-hydroxytryptamine receptor 2A | IC50 | = | 16.0 | nM | 7.8 | In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical memb... | - |
| 5-hydroxytryptamine receptor 2A | IC50 | = | 25.0 | nM | 7.6 | In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical memb... | - |
| Adrenergic receptor alpha-1 | IC50 | = | 86.0 | nM | 7.07 | Binding affinity towards Alpha-1 adrenergic receptor | - |
| Adrenergic receptor alpha-1 | IC50 | = | 100.0 | nM | 7.0 | Binding affinity towards Alpha-1 adrenergic receptor | - |
| D(2) dopamine receptor | IC50 | = | 100.0 | nM | 7.0 | Binding affinity towards dopamine D2 receptor | - |
| D(2) dopamine receptor | IC50 | = | 140.0 | nM | 6.85 | Binding affinity towards dopamine D2 receptor | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(94)80007-3 | Rattus norvegicus | 10 |
| - | 10.1016/0960-894X(94)80007-3 | Mus musculus | 8 |
| - | 10.1016/0960-894X(94)80007-3 | 5-hydroxytryptamine receptor 2A | 4 |
| - | 10.1016/0960-894X(94)80007-3 | Adrenergic receptor alpha-1 | 2 |
| - | 10.1016/0960-894X(94)80007-3 | D(2) dopamine receptor | 2 |
| - | 10.1016/0960-894X(94)80007-3 | Muscarinic acetylcholine receptor M4 | 2 |
| - | 10.1016/0960-894X(94)80007-3 | Histamine H1 receptor | 2 |
Data from ChEMBL 36 via Core Engine