Compound Detail
CHEMBL1365400
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Basic Information
| ChEMBL ID | CHEMBL1365400 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UZLYDACUZMAVMX-RAXLEYEMSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
350.4
MW (Da)
4.37
ALogP
4
HBA
1
HBD
53.4
PSA (Ų)
0.76
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.5
IC50 2 meas. best 5.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 CHEMBL1293302 | IC50 | 5.03 | 5.03 | 9411.0 | 1 |
| Protein Rev CHEMBL1293282 | IC50 | 4.77 | 4.77 | 16969.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.5 | 4.5 | 31884.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.41 | 4.41 | 39169.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 | IC50 | = | 9411.0 | nM | 5.03 | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput do... | - |
| Protein Rev | IC50 | = | 16969.0 | nM | 4.77 | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarizati... | - |
| Zinc finger protein mex-5 | EC50 | = | 31884.0 | nM | 4.5 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| RNA-binding protein pos-1 | EC50 | = | 39169.0 | nM | 4.41 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Data from ChEMBL 36 via Core Engine