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Compound Detail

CHEMBL1373467

DIPHENCYPRONE
Phase I
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Phase I
O=c1c(-c2ccccc2)c1-c1ccccc1

Basic Information

ChEMBL ID CHEMBL1373467
Name DIPHENCYPRONE
Phase Phase I
Structure Type MOL
InChI Key HCIBTBXNLVOFER-UHFFFAOYSA-N

Known Names

Diphencyprone Diphenylcyclopenone Diphenylcyclopropenone NSC-57541
1
Targets
7
Activities
1
Assay Types
0
PK Parameters
13
Publications
4
Known Names
1
Indications

Molecular Properties

206.2
MW (Da)
3.26
ALogP
1
HBA
0
HBD
17.1
PSA (Ų)
0.63
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product

Extended Properties

Molecular Formula C15H10O
MW 206.24
Aromatic Rings 3
Heavy Atoms 16
NP-Likeness 0.17

Indications

Hypersensitivity

Activity Summary

IC50 7 meas. best 5.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.77 5.4 1685.9 7

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
1255666 10.1021/jm00225a016 Rattus norvegicus 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1
- 10.6019/CHEMBL4513141 Candida albicans 1
- 10.6019/CHEMBL4513141 Cryptococcus neoformans 1
- 10.6019/CHEMBL4513141 Escherichia coli 1
- 10.6019/CHEMBL4513141 Klebsiella pneumoniae 1
- 10.6019/CHEMBL4513141 Pseudomonas aeruginosa 1
- 10.6019/CHEMBL4513141 Acinetobacter baumannii 1
- 10.6019/CHEMBL4513141 Staphylococcus aureus 1

Data from ChEMBL 36 via Core Engine