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Compound Detail

CHEMBL1376574

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CC(Oc1ccc(Cl)cc1Cl)c1nc(-c2ccc(NC(=O)c3ccccn3)cc2)no1

Basic Information

ChEMBL ID CHEMBL1376574
Phase Preclinical
Structure Type MOL
InChI Key PKPKZYMGBAIOIW-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

455.3
MW (Da)
5.83
ALogP
6
HBA
1
HBD
90.1
PSA (Ų)
0.39
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H16Cl2N4O3
MW 455.30
Aromatic Rings 4
Heavy Atoms 31
NP-Likeness -2.09

Activity Summary

EC50 2 meas. best 7.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 7.05 6.53 88.3 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine