Compound Detail
CHEMBL1381318
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Basic Information
| ChEMBL ID | CHEMBL1381318 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PZHGBWKPRMYCEF-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
239.2
MW (Da)
1.75
ALogP
4
HBA
2
HBD
80.4
PSA (Ų)
0.46
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.44
EC50 1 meas. best 4.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 CHEMBL4361 | IC50 | 5.44 | 5.44 | 3660.7 | 1 |
| Female germline-specific tumor suppressor gld-1 CHEMBL1293302 | IC50 | 5.38 | 5.38 | 4149.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.99 | 4.99 | 10361.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 | IC50 | = | 3660.67 | nM | 5.44 | PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibito... | - |
| Female germline-specific tumor suppressor gld-1 | IC50 | = | 4149.0 | nM | 5.38 | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput do... | - |
| Zinc finger protein mex-5 | EC50 | = | 10361.0 | nM | 4.99 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Data from ChEMBL 36 via Core Engine