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Compound Detail

CHEMBL1475884

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CCC(C)C(=O)N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)C3[C@](C)(C(=O)[C@H](OC(C)=O)C(=C1C)C2(C)C)[C@@H](O)C[C@H]1OC[C@@]31OC(C)=O

Basic Information

ChEMBL ID CHEMBL1475884
Phase Preclinical
Structure Type MOL
InChI Key OKEKLOJNCOIPIT-DYYKUXGFSA-N
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

833.9
MW (Da)
3.47
ALogP
14
HBA
4
HBD
221.3
PSA (Ų)
0.14
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C45H55NO14
MW 833.93
Aromatic Rings 2
Heavy Atoms 60
NP-Likeness 2.02

Activity Summary

EC50 2 meas. best 7.6
IC50 1 meas. best 6.61

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 7.6 6.4 25.0 2
Unchecked
CHEMBL612545
IC50 6.61 6.61 243.8 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine