Compound Detail
CHEMBL1480605
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Basic Information
| ChEMBL ID | CHEMBL1480605 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WVZZHZDFKZVJES-SNAWJCMRSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
281.2
MW (Da)
3.25
ALogP
5
HBA
1
HBD
81.2
PSA (Ų)
0.69
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.56
EC50 1 meas. best 5.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nuclear factor NF-kappa-B complex CHEMBL2094258 | EC50 | 5.63 | 5.63 | 2357.0 | 1 |
| Polyadenylate-binding protein 1 CHEMBL1293286 | IC50 | 4.56 | 4.505 | 27500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nuclear factor NF-kappa-B complex | EC50 | = | 2357.0 | nM | 5.63 | PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increa... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 27500.0 | nM | 4.56 | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetyla... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 35700.0 | nM | 4.45 | PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA... | - |
Data from ChEMBL 36 via Core Engine