Compound Detail
CHEMBL1500404
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Basic Information
| ChEMBL ID | CHEMBL1500404 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LHCHMNFZVIHXMW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
359.4
MW (Da)
3.40
ALogP
5
HBA
1
HBD
57.3
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Zinc finger protein GLI1 CHEMBL5007 | IC50 | 5.6 | 5.6 | 2520.0 | 1 |
| COUP transcription factor 2 CHEMBL1961790 | IC50 | 5.26 | 5.26 | 5539.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Zinc finger protein GLI1 | IC50 | = | 2520.0 | nM | 5.6 | PubChem BioAssay. Dose response confirmation of uHTS antagonist hits from Gli-SU... | - |
| COUP transcription factor 2 | IC50 | = | 5539.0 | nM | 5.26 | PubChem BioAssay. Luminescence-based cell-based high throughput dose response as... | - |
Data from ChEMBL 36 via Core Engine