Compound Detail
CHEMBL1536835
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Basic Information
| ChEMBL ID | CHEMBL1536835 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KRIPUEIIVKBRDC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
314.4
MW (Da)
2.04
ALogP
6
HBA
0
HBD
50.1
PSA (Ų)
0.82
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.53
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-degrading enzyme CHEMBL1293287 | EC50 | 4.53 | 4.51 | 29821.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-degrading enzyme | EC50 | = | 29821.0 | nM | 4.53 | PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-ba... | - |
| Insulin-degrading enzyme | EC50 | = | 32305.0 | nM | 4.49 | PUBCHEM_BIOASSAY: Fluorescence polarization-based cell-based high throughput dos... | - |
Data from ChEMBL 36 via Core Engine