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Compound Detail

CHEMBL1570251

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COc1ccc(OC)c(CCNC(=O)C2CCN(c3nnc(-n4cccc4)s3)CC2)c1

Basic Information

ChEMBL ID CHEMBL1570251
Phase Preclinical
Structure Type MOL
InChI Key JWVUGDAVVSSDRS-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

441.6
MW (Da)
2.92
ALogP
8
HBA
1
HBD
81.5
PSA (Ų)
0.58
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H27N5O3S
MW 441.56
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -1.63

Activity Summary

EC50 2 meas. best 5.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 5.82 5.68 1510.0 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine