Compound Detail
CHEMBL1583797
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Basic Information
| ChEMBL ID | CHEMBL1583797 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RXWHRXMUQBNLKF-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
388.3
MW (Da)
1.89
ALogP
7
HBA
3
HBD
162.9
PSA (Ų)
0.37
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.33
EC50 1 meas. best 4.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 4H CHEMBL1293274 | IC50 | 5.33 | 5.085 | 4620.0 | 2 |
| Apoptotic protease-activating factor 1 CHEMBL1795093 | EC50 | 4.98 | 4.98 | 10400.0 | 1 |
| Polyadenylate-binding protein 1 CHEMBL1293286 | IC50 | 4.12 | 4.12 | 76200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 4H | IC50 | = | 4620.0 | nM | 5.33 | PUBCHEM_BIOASSAY: SAR analysis for the identification of translation initiation ... | - |
| Apoptotic protease-activating factor 1 | EC50 | = | 10400.0 | nM | 4.98 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS Activators of the Apaf-1 Pa... | - |
| Eukaryotic translation initiation factor 4H | IC50 | = | 14580.0 | nM | 4.84 | PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 76200.0 | nM | 4.12 | PUBCHEM_BIOASSAY: SAR analysis for the identification of translation initiation ... | - |
Data from ChEMBL 36 via Core Engine