Compound Detail
CHEMBL162622
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL162622 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BGPOQKXCTILWFE-UHFFFAOYSA-N |
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
429.3
MW (Da)
3.28
ALogP
7
HBA
2
HBD
75.2
PSA (Ų)
0.62
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 9.19 | 7.885 | 0.7 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 0.65 | nM | 9.19 | Inhibit of phosphorylation of a tyrosine/glutamic acid copolymer by epidermal gr... | 9513602 |
| Epidermal growth factor receptor | IC50 | = | 0.7 | nM | 9.15 | Inhibition of tyrosine/glutamic acid copolymer phosphorylation by epidermal grow... | 9513602 |
| Epidermal growth factor receptor | IC50 | = | 7.9 | nM | 8.1 | Inhibition of autophosphorylation of epidermal growth factor receptor in A431 ce... | 9513602 |
| Epidermal growth factor receptor | IC50 | = | 7900.0 | nM | 5.1 | Inhibition of EGF-dependent autophosphorylation of EGF-R in A431 cells | 9513602 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9513602 | 10.1021/jm970641d | A-431 | 8 |
| 9513602 | 10.1021/jm970641d | Mus musculus | 8 |
| 9513602 | 10.1021/jm970641d | Epidermal growth factor receptor | 4 |
| 9513602 | 10.1021/jm970641d | MCF7 | 4 |
| 9513602 | 10.1021/jm970641d | SK-OV-3 | 3 |
| 9513602 | 10.1021/jm970641d | No relevant target | 1 |
| 9513602 | 10.1021/jm970641d | Receptor tyrosine-protein kinase erbB-2 | 1 |
| 9513602 | 10.1021/jm970641d | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 9513602 | 10.1021/jm970641d | Fibroblast growth factor receptor | 1 |
| 9513602 | 10.1021/jm970641d | Unchecked | 1 |
| 9513602 | 10.1021/jm970641d | Insulin receptor | 1 |
Data from ChEMBL 36 via Core Engine