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Compound Detail

CHEMBL1668604

1,4-DIMETHOXYBENZENE
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COc1ccc(OC)cc1

Basic Information

ChEMBL ID CHEMBL1668604
Name 1,4-DIMETHOXYBENZENE
Phase Preclinical
Structure Type MOL
InChI Key OHBQPCCCRFSCAX-UHFFFAOYSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

138.2
MW (Da)
1.70
ALogP
2
HBA
0
HBD
18.5
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C8H10O2
MW 138.17
Aromatic Rings 1
Heavy Atoms 10
NP-Likeness -0.18

Activity Summary

Ki 6 meas. best 5.47

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Carbonic anhydrase 2
CHEMBL205
Ki 5.47 5.47 3350.0 1
Carbonic anhydrase 7
CHEMBL2326
Ki 5.41 5.41 3880.0 1
Carbonic anhydrase 12
CHEMBL3242
Ki 5.4 5.4 4020.0 1
Carbonic anhydrase 9
CHEMBL3594
Ki 5.38 5.38 4150.0 1
Carbonic anhydrase 14
CHEMBL3510
Ki 5.17 5.17 6790.0 1
Carbonic anhydrase 1
CHEMBL261
Ki 5.09 5.09 8210.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26986086 10.1016/j.ejmech.2016.03.008 Unchecked 8
18020407 10.1021/jf071636d Trichoplusia ni 4
21282059 10.1016/j.bmc.2011.01.016 Carbonic anhydrase 1 1
21282059 10.1016/j.bmc.2011.01.016 Carbonic anhydrase 2 1
21282059 10.1016/j.bmc.2011.01.016 Carbonic anhydrase 9 1
21282059 10.1016/j.bmc.2011.01.016 Carbonic anhydrase 12 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 14 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 7 1
26986086 10.1016/j.ejmech.2016.03.008 No relevant target 1

Data from ChEMBL 36 via Core Engine