Assay Detail
Binding
CHEMBL2340799
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Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 5.85 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333963 | — | — | 1 | 6.48 |
| CHEMBL488609 | 2,6-DIMETHOXYBENZOIC ACID | — | 1 | 6.26 |
| CHEMBL1668605 | 1,2,4-TRIMETHOXYBENZENE | — | 1 | 6.20 |
| CHEMBL95308 | 3,5-DIHYDROXYBENZOIC ACID | — | 1 | 6.19 |
| CHEMBL2333960 | — | — | 1 | 6.16 |
| CHEMBL37537 | PROTOCATECHUIC ACID | — | 1 | 6.16 |
| CHEMBL2333956 | — | — | 1 | 6.15 |
| CHEMBL1940391 | ISOPROPYL 3-(4-HYDROXYPHENYL)ACRYLATE | — | 1 | 6.14 |
| CHEMBL466810 | — | — | 1 | 6.13 |
| CHEMBL2333958 | — | — | 1 | 6.13 |
| CHEMBL118903 | VERATRIC ACID | — | 1 | 6.13 |
| CHEMBL2333961 | — | — | 1 | 6.13 |
| CHEMBL2333586 | — | — | 1 | 6.12 |
| CHEMBL486218 | METHYL 3,5-DIHYDROXYBENZOATE | — | 1 | 6.11 |
| CHEMBL2333584 | — | — | 1 | 6.11 |
| CHEMBL2333589 | — | — | 1 | 6.11 |
| CHEMBL2074640 | ETHYL P-COUMARATE | — | 1 | 6.10 |
| CHEMBL1978880 | METHYL 2,5-DIHYDROXYBENZOATE | — | 1 | 6.10 |
| CHEMBL2333962 | ISOPROPYL 4-HYDROXYBENZOATE | — | 1 | 6.09 |
| CHEMBL2333587 | — | — | 1 | 6.09 |
| CHEMBL2333957 | — | — | 1 | 6.09 |
| CHEMBL448695 | — | — | 1 | 6.08 |
| CHEMBL146816 | METHYL P-HYDROXYCINNAMATE | — | 1 | 6.08 |
| CHEMBL2333588 | — | — | 1 | 6.08 |
| CHEMBL2333585 | — | — | 1 | 6.08 |
| CHEMBL2333590 | — | — | 1 | 6.07 |
| CHEMBL486026 | METHYL 2,4-DIHYDROXYBENZOATE | — | 1 | 6.07 |
| CHEMBL486216 | — | — | 1 | 6.07 |
| CHEMBL486027 | METHYL PROTOCATECHUATE | — | 1 | 6.05 |
| CHEMBL325372 | METHYLPARABEN | -1.0 | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333963 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL488609 | 2,6-DIMETHOXYBENZOIC ACID | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL1668605 | 1,2,4-TRIMETHOXYBENZENE | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL95308 | 3,5-DIHYDROXYBENZOIC ACID | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL2333960 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL37537 | PROTOCATECHUIC ACID | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL2333956 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL1940391 | ISOPROPYL 3-(4-HYDROXYPHENYL)ACRYLATE | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL2333961 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL118903 | VERATRIC ACID | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL2333958 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL466810 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL2333586 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL2333589 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL2333584 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL486218 | METHYL 3,5-DIHYDROXYBENZOATE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL2074640 | ETHYL P-COUMARATE | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1978880 | METHYL 2,5-DIHYDROXYBENZOATE | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL2333957 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL2333587 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL2333962 | ISOPROPYL 4-HYDROXYBENZOATE | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL448695 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL146816 | METHYL P-HYDROXYCINNAMATE | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL2333588 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL2333585 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL2333590 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL486026 | METHYL 2,4-DIHYDROXYBENZOATE | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL486216 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL486027 | METHYL PROTOCATECHUATE | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL325372 | METHYLPARABEN | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL454808 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL2333959 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL1668604 | 1,4-DIMETHOXYBENZENE | Ki | = | 6790.0 | nM | 5.17 |
| CHEMBL1668603 | 1,2-DIMETHOXYBENZENE | Ki | = | 6830.0 | nM | 5.17 |
| CHEMBL269755 | 3-AMINOPHENOL | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL15841 | ETHYLPARABEN | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL1461 | GENTISIC ACID | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | Ki | = | 70000.0 | nM | 4.16 |