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Compound Detail

CHEMBL2333587

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CCOC(=O)c1c(O)cccc1O

Basic Information

ChEMBL ID CHEMBL2333587
Phase Preclinical
Structure Type MOL
InChI Key MIGILBRMELSWJT-UHFFFAOYSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

182.2
MW (Da)
1.27
ALogP
4
HBA
2
HBD
66.8
PSA (Ų)
0.68
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H10O4
MW 182.18
Aromatic Rings 1
Heavy Atoms 13
NP-Likeness 0.13

Activity Summary

Ki 6 meas. best 6.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Carbonic anhydrase 2
CHEMBL205
Ki 6.25 6.25 560.0 1
Carbonic anhydrase 1
CHEMBL261
Ki 6.17 6.17 670.0 1
Carbonic anhydrase 7
CHEMBL2326
Ki 6.12 6.12 760.0 1
Carbonic anhydrase 9
CHEMBL3594
Ki 6.11 6.11 780.0 1
Carbonic anhydrase 14
CHEMBL3510
Ki 6.09 6.09 820.0 1
Carbonic anhydrase 12
CHEMBL3242
Ki 6.08 6.08 840.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 14 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 12 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 9 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 7 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 2 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 1 1

Data from ChEMBL 36 via Core Engine