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Compound Detail

CHEMBL2333957

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Cc1cc(C)[n+](CCc2ccccc2C)c(C)c1.[O-][Cl+3]([O-])([O-])[O-]

Basic Information

ChEMBL ID CHEMBL2333957
Phase Preclinical
Structure Type MOL
InChI Key NTIIQUNUOPKFJD-UHFFFAOYSA-M
Parent Compound CHEMBL2365964
Active Moiety CHEMBL2365964
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

240.4
MW (Da)
3.45
ALogP
0
HBA
0
HBD
3.9
PSA (Ų)
0.72
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H22ClNO4
MW 339.82
Aromatic Rings 2
Heavy Atoms 18
NP-Likeness -0.50

Activity Summary

Ki 6 meas. best 6.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Carbonic anhydrase 12
CHEMBL3242
Ki 6.12 6.12 760.0 1
Carbonic anhydrase 14
CHEMBL3510
Ki 6.09 6.09 810.0 1
Carbonic anhydrase 9
CHEMBL3594
Ki 6.08 6.08 830.0 1
Carbonic anhydrase 2
CHEMBL205
Ki 5.17 5.17 6800.0 1
Carbonic anhydrase 1
CHEMBL261
Ki 5.13 5.13 7400.0 1
Carbonic anhydrase 7
CHEMBL2326
Ki 5.06 5.06 8700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 14 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 12 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 9 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 7 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 2 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 1 1

Data from ChEMBL 36 via Core Engine