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Compound Detail

CHEMBL2333960

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Cc1cc(C)[n+](-c2cccc(O)c2)c(C)c1.[O-][Cl+3]([O-])([O-])[O-]

Basic Information

ChEMBL ID CHEMBL2333960
Phase Preclinical
Structure Type MOL
InChI Key XGOGSWTWVBKINQ-UHFFFAOYSA-N
Parent Compound CHEMBL2365943
Active Moiety CHEMBL2365943
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

214.3
MW (Da)
2.59
ALogP
1
HBA
1
HBD
24.1
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H16ClNO5
MW 313.74
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness -0.12

Activity Summary

Ki 6 meas. best 6.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Carbonic anhydrase 2
CHEMBL205
Ki 6.5 6.5 320.0 1
Carbonic anhydrase 1
CHEMBL261
Ki 6.41 6.41 390.0 1
Carbonic anhydrase 12
CHEMBL3242
Ki 6.27 6.27 540.0 1
Carbonic anhydrase 9
CHEMBL3594
Ki 6.17 6.17 680.0 1
Carbonic anhydrase 14
CHEMBL3510
Ki 6.16 6.16 700.0 1
Carbonic anhydrase 7
CHEMBL2326
Ki 6.14 6.14 720.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 14 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 12 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 9 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 7 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 2 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 1 1

Data from ChEMBL 36 via Core Engine