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Compound Detail

CHEMBL2074640

ETHYL P-COUMARATE
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CCOC(=O)/C=C/c1ccc(O)cc1

Basic Information

ChEMBL ID CHEMBL2074640
Name ETHYL P-COUMARATE
Phase Preclinical
Structure Type MOL
InChI Key ZOQCEVXVQCPESC-VMPITWQZSA-N
6
Targets
7
Activities
2
Assay Types
0
PK Parameters
14
Publications
0
Known Names

Molecular Properties

192.2
MW (Da)
1.97
ALogP
3
HBA
1
HBD
46.5
PSA (Ų)
0.59
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C11H12O3
MW 192.21
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness 0.54

Activity Summary

Ki 6 meas. best 6.5
IC50 1 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Carbonic anhydrase 1
CHEMBL261
Ki 6.5 6.5 320.0 1
Carbonic anhydrase 12
CHEMBL3242
Ki 6.31 6.31 490.0 1
Carbonic anhydrase 9
CHEMBL3594
Ki 6.21 6.21 610.0 1
Carbonic anhydrase 2
CHEMBL205
Ki 6.15 6.15 710.0 1
Carbonic anhydrase 14
CHEMBL3510
Ki 6.1 6.1 800.0 1
Carbonic anhydrase 7
CHEMBL2326
Ki 6.07 6.07 850.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C4MD00022F NON-PROTEIN TARGET 5
8704323 10.1271/bbb.60.909 Athelia rolfsii 2
8704323 10.1271/bbb.60.909 Pythium 2
9786900 10.1074/jbc.273.44.28959 Monocarboxylate transporter 1 1
9786900 10.1074/jbc.273.44.28959 Monocarboxylate transporter 2 1
- 10.1007/s00044-011-9713-2 NON-PROTEIN TARGET 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 14 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 12 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 9 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 7 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 2 1
22668600 10.1016/j.bmc.2012.05.019 Carbonic anhydrase 1 1
30771602 10.1016/j.ejmech.2019.02.006 Unchecked 1
34225166 10.1016/j.bmc.2021.116299 Unchecked 1

Data from ChEMBL 36 via Core Engine